A substrate of the CYP450 isoform CYP2C19

(S)-Mephenytoin – 10 mg

Brand:
Cayman
CAS:
70989-04-7
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase.{23859} CYP2C19 metabolizes a variety of therapeutic agents, including omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates.{23861} Genetic defects in CYP2C19 result in poor metabolism of these compounds, and (S)-mephenytoin can be used to screen for such mutations by assaying its metabolites in urine.{23861,23858,23857} (S)-Mephenytoin has anticonvulsant activities.{23860}  

 

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SKU: 11913 - 10 mg Category:

Description

A substrate of the CYP450 isoform CYP2C19, also known as mephenytoin 4-hydroxylase; can be used to screen for mutations in CYP2C19 by assaying its metabolites in urine

Formal name: (5S)-5-ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione

Synonyms:  (+)-Mephenytoin|(S)-5-ethyl-3-methyl-5-Phenylhydantoin

Molecular weight: 218.3

CAS: 70989-04-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Research Area|Neuroscience|Seizure Disorders||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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