An enantiomer of ibuprofen that more potently inhibits COX activity

(S)-Ibuprofen – 500 mg

Brand:
Cayman
CAS:
51146-56-6
Storage:
-20
UN-No:
Non-Hazardous - /

Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, µM, respectively).{1286} It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form.{27415,27418} (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 µM, respectively).{6935} However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 µM).{27418} A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.{27417,1208,27416}  

 

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An enantiomer of ibuprofen that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form; also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 µM, respectively)

Formal name: (αS)-α-methyl-4-(2-methylpropyl)-benzeneacetic acid

Synonyms:  (+)-Ibuprofen|Dexibuprofen

Molecular weight: 206.3

CAS: 51146-56-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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