The COX-active enantiomer of flurbiprofen (IC50s = 0.48 and 0.47 µM for COX-1 and COX-2

(S)-Flurbiprofen – 100 mg

Brand:
Cayman
CAS:
51543-39-6
Storage:
22
UN-No:
Non-Hazardous - 2811 / 6.1

(S)-Flurbiprofen is the COX-active enantiomer of the non-selective COX inhibitor flurbiprofen (Item No. 70250) with IC50 values of 0.48 and 0.47 µM for COX-1 and COX-2, respectively, in guinea pig whole blood.{16202} It inhibits the release of 6-keto prostaglandin F1α (6-keto-PGF1α; Item No. 15210) and thromboxane B2 (TXB2; Item No. 19030) from rat whole blood, gastric mucosa, lung, and jejunal tissue ex vivo in a dose-dependent manner.{43119} (S)-Flurbiprofen (1 nM) inhibits basal and bradykinin-, serotonin-, and histamine-stimulated prostaglandin E2 (PGE2) release from isolated skin flaps of rat lower hind paws.{43120} It also inhibits release of the neuroinflammatory marker calcitonin gene-related peptide (CGRP; Item Nos. 24405 | 24725 | 24728) when used at a concentration of 1 μM. In vivo, (S)-flurbiprofen reduces the number of flinches per minute in the formalin test in rats, indicating antinociceptive activity.{43121}  

 

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SKU: 10004207 - 100 mg Category:

Description

The COX-active enantiomer of flurbiprofen (IC50s = 0.48 and 0.47 µM for COX-1 and COX-2, respectively); inhibits the release of 6-keto-PGF1α and TXB2 from rat whole blood, gastric mucosa, lung, and jejunal tissue ex vivo; inhibits basal and bradykinin-, serotonin-, and histamine-stimulated PGE2 release from isolated skin flaps of rat lower hind paws at 1 nM; inhibits release of CGRP at 1 μM; reduces the number of flinches per minute in the formalin test in rats

Formal name: (S)-(+)-2-fluoro-α-methyl-4-biphenylacetic acid

Synonyms: 

Molecular weight: 244.3

CAS: 51543-39-6

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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