The naturally occurring enantiomer of equol that demonstrates ER agonist activity similar to that of genistein (EC50 = 85 and 65 nM for human ERα and ERβ

(S)-Equol – 10 mg

Brand:
Cayman
CAS:
531-95-3
Storage:
-20
UN-No:
Non-Hazardous - /

Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora.{16628,16720} The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein.{16720} (S)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM).{16628} (S)-equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.{17382}  

 

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SKU: 10010173 - 10 mg Category:

Description

The naturally occurring enantiomer of equol that demonstrates ER agonist activity similar to that of genistein (EC50 = 85 and 65 nM for human ERα and ERβ, respectively); preferentially binds ERβ (Ki = 0.73 nM) with lower affinity for ERα (Ki = 6.4 nM)

Formal name: (S)-3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol

Synonyms:  (−)-Equol|4′,7-Dihydroxyisoflavan|4′,7-Isoflavandiol

Molecular weight: 242.3

CAS: 531-95-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Androgens||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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