A prodrug form of a P2Y12 antagonist; its thiol metabolite antagonizes purine binding to the platelet puringenic receptor P2Y12 (Ki = 316 nM in human platelets); is metabolized by CYP2C19 in rat liver and inhibits ADP-induced platelet aggregation ex vivo

(S)-(+)-Clopidogrel (sulfate) – 100 mg

Brand:
Cayman
CAS:
120202-66-6
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-(+)-Clopidogrel is the functional enantiomer of clopidogrel (Item No. 13657) and a prodrug whose thiol metabolite antagonizes purine binding to the platelet purinergic receptor P2Y12 (Ki = 316 nM in human platelets).{19256} It is metabolized by the cytochrome P450 (CYP) isoform CYP2C19 in rat liver and inhibits ADP-induced platelet aggregation ex vivo.{19259} Formulations containing (S)-(+)-clopidogrel have been used in combination with aspirin to prevent vascular ischemic events in patients with acute coronary syndromes.  

 

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Description

A prodrug form of a P2Y12 antagonist; its thiol metabolite antagonizes purine binding to the platelet puringenic receptor P2Y12 (Ki = 316 nM in human platelets); is metabolized by CYP2C19 in rat liver and inhibits ADP-induced platelet aggregation ex vivo

Formal name: S-α-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetic acid, methyl ester, monosulfate

Synonyms:  SR 25990C

Molecular weight: 419.9

CAS: 120202-66-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases

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