A selective inhibitor of SMYD2 with IC50 values of 27 nM and in vitro and in whole cells

(S)-BAY-598 – 1 mg

Brand:
Cayman
CAS:
1906919-67-2
Storage:
2-8
UN-No:
Non-Hazardous - /

(S)-BAY-598 is a selective inhibitor of SMYD2. It inhibits the methylation of p53 at lysine 370 in vitro and in whole cells with IC50 values of 27 nM and Structural Genomics Consortium (SGC). The negative control, BAY-369, for (S)-BAY-598 is also available exclusively through the SGC. You can submit a request to receive the negative control here.  

 

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Description

A selective inhibitor of SMYD2 with IC50 values of 27 nM and in vitro and in whole cells, respectively; exhibits 100-fold selectivity for SMYD2 over other enzymes tested

Formal name: (S,Z)-N-(1-(N’-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide

Synonyms: 

Molecular weight: 525.3

CAS: 1906919-67-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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