A derivative of glutathione; more stable in plasma than GSH; converted to GSH by intracellular thioesterases; increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency at 50 μM; induces apoptosis in Daudi

S-Acetyl-L-glutathione – 5 g

Brand:
Cayman
CAS:
3054-47-5
Storage:
-20
UN-No:
Non-Hazardous - /

S-Acetyl-L-glutathione is a derivative of glutathione (GSH; Item No. 10007461).{46706} It is more stable in plasma than GSH and, unlike GSH, can be taken up into cells, where it is converted to GSH by intracellular thioesterases.{46706,46708,57054} S-Acetyl-L-glutathione (50 μM) increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency.{46706} It induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells when used at a concentration of 5 mM.{46707} It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.{46708} S-Acetyl-L-glutathione (6.25 μg/g per day), but not GSH, increases survival in a mouse model of HSV-1 infection.  

 

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SKU: 29624 - 5 g Category:

Description

A derivative of glutathione; more stable in plasma than GSH; converted to GSH by intracellular thioesterases; increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency at 50 μM; induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells at 5 mM; inhibits the replication of HSV-1 in human foreskin fibroblasts at 5 and 10 mM; increases survival in a mouse model of HSV-1 infection at 6.25 μg/g per day

Formal name: L-γ-glutamyl-S-acetyl-L-cysteinyl-glycine

Synonyms:  S-Acetylglutathione

Molecular weight: 349.4

CAS: 3054-47-5

Purity: ≥98%

Formulation: A crystalline solid

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