A ubiquitous methyl donor involved in a wide variety of biological reactions

S-(5′-Adenosyl)-L-methionine chloride (hydrochloride) – 2.5 mg

Brand:
Cayman
CAS:
86867-01-8
Storage:
-80
UN-No:
Non-Hazardous - /

S-(5′-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases.{19419,16924,16845} The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine (Item No. 13603).{16924} SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine.{16924} Cayman Chemical’s SAM has been purified to remove all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman’s SAM contains no S-methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.  

 

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Description

A ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases

Formal name: 5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-adenosine, dihydrochloride

Synonyms:  AdoMet|SAM

Molecular weight: 507.8

CAS: 86867-01-8

Purity: ≥95%

Formulation: A lyophilized powder

Product Type|Biochemicals||Research Area|Epigenetics, Transcription, & Translation|Writers|DNA/RNA Methylation||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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