A nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM; IC50s = 4.6 and 3.6 nM in rat and human

S-(4-Nitrobenzyl)-6-thioinosine – 50 mg

Brand:
Cayman
CAS:
38048-32-7
Storage:
-20
UN-No:
Non-Hazardous - /

S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM; IC50s = 4.6 and 3.6 nM in rat and human, respectively).{26791,26792} It blocks adenosine flux across the plasma membrane, thereby potentiating the interaction of extracellular adenosine with purinoreceptors, which can affect cardiac signaling associated with adenosine.{26792}  

 

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Description

A nucleoside analog that competitively inhibits the equilibrative nucleoside transporter 1 (Kd = 0.1-1.0 nM; IC50s = 4.6 and 3.6 nM in rat and human, respectively); blocks adenosine uptake, thereby potentiating the interaction of extracellular adenosine with purinoreceptors

Formal name: S-4-nitrophenylmethyl-6-thioinosine

Synonyms:  NBMPR|NBTI|NSC 296962

Molecular weight: 419.4

CAS: 38048-32-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System

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