Description
An inverse agonist of 5-HT receptor subtypes 5-HT2CINI and 5-HT2CVSV (Ki = 6.6 and 8.9 nM, respectively); an antagonist of the 5-HT2A receptor and the α2B-adrenergic receptors (Ki = 5.8 nM for both receptors); is greater than 70-fold selective for these receptors in a panel of 80 receptors, enzymes, and ion channels; reduces binding of GTPγS to Gαq and decreases the activity of PLC in HEK293 cells expressing 5-HT2CINI receptors (EC50s = 38 and 18.6 nM, respectively) and in CHO cells expressing 5-HT2CVSV receptors (EC50s = 38 and 18.6 nM, respectively); S 32212 (2.5 mg/kg) decreases head twitching, penile erections, and drug discrimination induced by 5-HT receptor agonists in mice and rats; reduces immobility in the forced swim test and decreases marble burying in mice and rats at 10 and 40 mg/kg, indicating anti-depressant-like and anxiolytic activities.
Formal name: 1,2-dihydro-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3H-benz[e]indole-3-carboxamide, monohydrochloride
Synonyms:
Molecular weight: 453
CAS: 847871-78-7
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Depression
