A more stable form of (–)-blebbistatin; less inherent fluorescence than (–)-blebbistatin while retaining the activity; has the same stereochemistry as (–)-blebbistatin

(S)-3′-hydroxy Blebbistatin – 5 mg

Brand:
Cayman
CAS:
2097136-42-8
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-3’-hydroxy Blebbistatin is a more stable and less phototoxic form of (–)-blebbistatin (Item No. 13013), which is a selective cell-permeable inhibitor of non-muscle myosin II ATPases.{16452,17037} (–)-Blebbistatin rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 µM), while poorly inhibiting smooth muscle myosin (IC50 = 80 µM).{17036} Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.{17038,24037} The addition of a 3’-hydroxy group decreases the inherent fluorescence while retaining the activity of (–)-blebbistatin.{40574} (S)-3′-hydroxy-Blebbistatin has the same stereochemistry as the active (–)-blebbistatin enantiomer.  

 

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SKU: 24169 - 5 mg Category:

Description

A more stable form of (–)-blebbistatin; less inherent fluorescence than (–)-blebbistatin while retaining the activity; has the same stereochemistry as (–)-blebbistatin

Formal name: 1,2,3,3aS-tetrahydro-3a-hydroxy-1-(3-hydroxyphenyl)-6-methyl-4H-pyrrolo[2,3-b]quinolin-4-one

Synonyms:  (−)-3′-hydroxy Blebbistatin|m-hydroxy-Blebbistatin|meta-hydroxy-Blebbistatin

Molecular weight: 308.3

CAS: 2097136-42-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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