A mycotoxin; inhibits ribonuclease H in rat liver and ribonucleases H1

(+)-Rugulosin – 1 mg

Brand:
Cayman
CAS:
23537-16-8
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Rugulosin is a pigment and mycotoxin produced by certain fungi.{37202} It inhibits HIV-1 integrase activity with IC50 values of 19 and 25 µM in coupled and strand transfer assays, respectively.{37200} It also inhibits ribonuclease H in rat liver by 83% at a concentration of 157 µM and ribonucleases H1, H2, and H3 in T. pyriformis by 100, 99, and 100%, respectively, at a concentration of 313 µM.{37201} (+)-Rugulosin leads to hepatic injury and liver cell hyperplasia in mice when administered in the diet.{37202} It is cytotoxic to insect cells but not mammalian C6/36, L929, and HepG2 cells (ID50s = 1.2, >200, 23.7, and >200 µg/ml, respectively).{37203}  

 

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SKU: 23558 - 1 mg Category:

Description

A mycotoxin; inhibits ribonuclease H in rat liver and ribonucleases H1, H2, and H3 in T. pyriformis; inhibits HIV-1 integrase activity (IC50s = 19 and 25 µM in coupled and strand transfer assays, respectively); inhibits ribonuclease H in rat liver by 83% at a concentration of 157 µM and ribonucleases H1, H2, and H3 in T. pyriformis by 100, 99, and 100%, respectively, at a concentration of 313 µM; leads to hepatic injury and liver cell hyperplasia when administered to mice in the diet; cytotoxic to insect cells but not mammalian C6/36, L929, and HepG2 cells (ID50s = 1.2, >200, 23.7, and >200 µg/ml, respectively)

Formal name: (5aS,6R,13aS,14R,17S,18R,19R,20S)-1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-5H,6H-6,13a,5a,14-[1,2,3,4]butanetetraylcycloocta[1,2-b:5,6-b’]dinaphthalene-5,8,13,16(14H)-tetrone

Synonyms:  NSC 160880|NSC 249990|Rugulosin A

Molecular weight: 542.5

CAS: 23537-16-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Plant Biology

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