A natural mycotoxin and selective inhibitor of PP2A (IC50 = 170 nM); causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts

Rubratoxin A – 250 µg

Brand:
Cayman
CAS:
22467-31-8
Storage:
-20
UN-No:
Non-Hazardous - /

Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A; IC50 = 170 nM).{31275} It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells treated for three hours at 20 µM.{31275} It causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts.{31275}  

 

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Description

A natural mycotoxin and selective inhibitor of PP2A (IC50 = 170 nM); causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts

Formal name: (4S,5R,10R)-rel-10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-4,5,8,9,10,11-hexahydro-4,8-dihydroxy-5-[(1S)-1-hydroxyheptyl]-1H-cyclonona[1,2-c:5,6-c’]difuran-1,3,6-trione

Synonyms:  BRN 1633008|HSDB 3532

Molecular weight: 520.5

CAS: 22467-31-8

Purity: ≥95%

Formulation: A powder

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cell Biology|Cell Signaling

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