Binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM

RTA 408 – 10 mg

Brand:
Cayman
CAS:
1474034-05-3
Storage:
-20
UN-No:
Non-Hazardous - /

RTA 408 is a synthetic triterpenoid that binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM.{29061} In this way, it suppresses the generation of nitric oxide and pro-inflammatory cytokines in macrophages stimulated with IFN-γ.{29061} At higher concentrations, RTA 408 inhibits tumor cell growth (GI50 = 260 nM), blocks NF-κB signaling, and decreases levels of cyclin D1.{29061} Topical application of RTA 408 activates Nrf2 and provides cytoprotective effects.{29062,29063}  

 

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Description

Binds Keap1 and attenuates the degradation of Nrf2 at concentrations ≤25 nM, suppressing inflammatory signaling; inhibits tumor cell growth (GI50 = 260 nM), blocks NF-κB signaling, and decreases levels of cyclinD1; activates Nrf2 and provides cytoprotective effects when applied topically

Formal name: N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-propanamide

Synonyms:  ​Omaveloxolone

Molecular weight: 554.7

CAS: 1474034-05-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity

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