An inhibitor of RSV; binds to RSV nucleoprotein (Kd = 1.31 μM); reduces plaque formation by RSS

RSV-604 – 1 mg

Brand:
Cayman
CAS:
676128-63-5
Storage:
-20
UN-No:
Non-Hazardous - /

RSV-604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM).{47701} It reduces plaque formation by RSS, Long, A2, and B RSV strains (EC50s = 0.9, 0.8, 0.5, and 0.6 μM, respectively) and is active against 40 RSV clinical isolates (mean EC50 = 0.8 μM).{47702} RSV-604 increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM) and inhibits RSV replication in human airway epithelial (HAE) cell monolayers following mucosal inoculation.  

 

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SKU: 29041 - 1 mg Category:

Description

An inhibitor of RSV; binds to RSV nucleoprotein (Kd = 1.31 μM); reduces plaque formation by RSS, Long, A2, and B RSV strains (EC50s = 0.9, 0.8, 0.5, and 0.6 μM, respectively); active against 40 RSV clinical isolates (mean EC50 = 0.8 μM); increases viability of RSV-infected HEp-2 cells (EC50 = 0.86 μM); inhibits RSV replication in HAE cell monolayers following mucosal inoculation

Formal name: N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N′-(2-fluorophenyl)-urea

Synonyms: 

Molecular weight: 388.4

CAS: 676128-63-5

Purity: ≥98%

Formulation: A solid

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