A selective inhibitor of CHOKα (IC50s = 1 and >50 μM for CHOKα and β

RSM-932A – 5 mg

Brand:
Cayman
CAS:
850807-63-5
Storage:
-20
UN-No:
Non-Hazardous - /

RSM-932A is a selective inhibitor of choline kinase α (CHOKα; IC50s = 1 and >50 μM for CHOKα and β, respectively).{38678} It induces apoptosis via CHOP signaling and endoplasmic reticulum (ER) stress in MDA-MB-231, MCF-7, SW620, and H460 cancer cells, but it only induces cell cycle arrest and not apoptosis in NCM460 and MCF-10A normal epithelial cells.{38679} RSM-932A inhibits the growth of HT-29 colon cancer cells in vitro (IC50 = 1.15 μM) and in vivo in a mouse xenograft model (ED50 = 7.5 mg/kg).{38678}  

 

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Description

A selective inhibitor of CHOKα (IC50s = 1 and >50 μM for CHOKα and β, respectively); induces apoptosis via CHOP signaling and ER stress in MDA-MB-231, MCF-7, SW620, and H460 cancer cells; inhibits the growth of HT-29 colon cancer cells in vitro (IC50 = 1.15 μM) and in vivo in a mouse xenograft model (ED50 = 7.5 mg/kg) ,

Formal name: 1,1′-[[[1,1′-biphenyl]-4,4′-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium, dibromide

Synonyms: 

Molecular weight: 877.5

CAS: 850807-63-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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