A chemokine receptor CCR2 antagonist (IC50 = 0.36 µM); inhibits the related CCR1 receptor with an IC50 value of 17.8 µM and inhibits adrenergic α1a

RS 102895 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
1173022-16-6
Storage:
-20
UN-No:
Non-Hazardous - /

The chemokine CCL2, also known as monocyte chemotactic protein-1 (MCP-1), stimulates leukocyte chemotaxis to sites of inflammation via signaling through the MCP-1 receptor, CCR2. RS 102895 is a spiropiperidine compound that acts as a CCR2 antagonist (IC50 = 0.36 µM).{29459} It inhibits the related CCR1 receptor with an IC50 value of 17.8 µM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC50 values of 0.13, 0.32, and 47 µM, respectively.{29459} RS 102895 prevents chemotaxis of THP-1 cells (IC50 = 1.7 µM) when MCP-1 is presented as a chemoattractant.{29459}  

 

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Description

A chemokine receptor CCR2 antagonist (IC50 = 0.36 µM); inhibits the related CCR1 receptor with an IC50 value of 17.8 µM and inhibits adrenergic α1a, α1d, and 5HT1A receptors with IC50 values of 0.13, 0.32, and 47 µM, respectively

Formal name: 1′-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-piperidin]-2(1H)-one, monohydrochloride

Synonyms: 

Molecular weight: 426.9

CAS: 1173022-16-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Innate Immunity

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