Description
An anticancer agent; inhibits growth in a panel of 12 cancer cell lines (IC50s = 1.8-6 μM), an effect that is enhanced in SCC VII cells under hypoxic conditions; increases intracellular ROS levels in HT-29 and SCC VII cells; induces apoptosis in SCC VII, HL-60, and Daudi cells at 5, 5, and 4 μM, respectively; reduces tumor growth and enhances radiation-induced tumor growth reduction in an SCC VII murine squamous cell carcinoma model at 5 mg/kg per day for five days; pre-incubation of red blood cells and hemolysate at 3 mM increases nitrite-induced NO release under hypoxic conditions; decreases parasitemia and increases survival in a mouse model of P. berghei ANKA infection at 10 mg/kg
Formal name: 2-bromo-1-(3,3-dinitro-1-azetidinyl)-ethanone
Synonyms: ABDNAZ
Molecular weight: 268
CAS: 925206-65-1
Purity: ≥95%
Formulation: A solid
