A stable

Rp-8-pCPT-Cyclic GMPS (sodium salt) – 1 mg

Brand:
Cayman
CAS:
208445-07-2
Storage:
-20
UN-No:
Non-Hazardous - /

Rp-8-pCPT-Cyclic GMPS is a stable, cell-permeable cGMP analog that competitively inhibits cGMP-dependent protein kinases (cGKs), including cGK Iα and cGK II (IC50s = 18.3 and 0.16 µM, respectively).{29685} The pCPT (p-chlorophenylthio) group at the 8-position of the purine increases both enzyme affinity and membrane permeability over related compounds.{29686} At 10 µM, it blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1 (Item No. 82220).{29702}  

 

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Description

A stable, cell-permeable cGMP analog that competitively inhibits cGMP-dependent protein kinases (cGKs), including cGK Iα and cGK II (IC50s = 18.3 and 0.16 µM, respectively); blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1

Formal name: 8-[(4-chlorophenyl)thio]-cyclic 3’,5’-[hydrogen [P(R)]-phosphorothioate] guanosine, monosodium salt

Synonyms:  Rp-8-pCPT-cGMPS

Molecular weight: 525.9

CAS: 208445-07-2

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKD & PKG||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling

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