A cell-permeable cGMP analog that binds cGK without activating it

Rp-8-bromo-Cyclic GMPS (sodium salt) – 1 mg

Brand:
Cayman
CAS:
208445-06-1
Storage:
-20
UN-No:
Non-Hazardous - /

8-bromo-cGMP (Item No. 15992) is a cell-permeable analog of cGMP that exhibits resistance to hydrolysis by phosphodiesterases. It preferentially activates cGMP-dependent protein kinase (cGK).{25938} Rp-8-bromo-Cyclic GMPS (Rp-8-bromo-cGMPS) is a cell-permeable cGMP analog that adds an equatorial exocyclic (Rp) sulfur substitution in the axial position of the cyclophosphate ring of 8-bromo-cGMP. Like 8-bromo-cGMP, Rp-8-bromo-cGMPS is resistant to hydrolysis by phosphodiesterases. This Rp isomer binds cGK without activating it, resulting in competitive inhibition.{29700,29701} At 10 µM, it blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1 (Item No. 82220).{29702}  

 

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Description

A cell-permeable cGMP analog that binds cGK without activating it, resulting in competitive inhibition; blocks the relaxation of rat tail arteries induced by the nitric oxide donor SIN-1

Formal name: 8-bromo-guanosine cyclic 3′,5′-[(R)-(hydrogen phosphorothioate)], monosodium salt

Synonyms:  Rp-8-bromo-cGMPS

Molecular weight: 462.2

CAS: 208445-06-1

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKD & PKG||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling

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