A membrane-permeable antagonist of cAMP-dependent PKAs; resistant to hydrolysis by cyclic nucleotide PDEs

Rp-8-bromo-Cyclic AMPS (sodium salt) – 500 µg

Brand:
Cayman
CAS:
925456-59-3
Storage:
-20
UN-No:
Non-Hazardous - /

Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.{26215,28143} It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II from bovine heart.{28143}  

 

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Description

A membrane-permeable antagonist of cAMP-dependent PKAs; resistant to hydrolysis by cyclic nucleotide PDEs

Formal name: 8-bromo-adenosine cyclic 3′,5′-[hydrogen [P(R)]-phosphorothioate], monosodium salt

Synonyms:  8-Bromoadenosine 3′,5′-cyclic monophosphorothioate, Rp-isomer|Rp-8-Br-cAMPS|Rp-8-bromo-cAMPS

Molecular weight: 446.1

CAS: 925456-59-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKA||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|cAMP Signaling

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