Inhibits PKCδ (IC50 = 3 μM)

Rottlerin – 50 mg

Brand:
Cayman
CAS:
82-08-6
Storage:
-20
UN-No:
Non-Hazardous - /

Rottlerin was originally identified as an inhibitor of PKCδ (IC50 = 3 μM), but can also inhibit CAM kinase III and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 μM, respectively).{22472,12847} It can act as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1.{17472} Rottlerin has also been shown to have neuroprotective effects in an MPTP animal model of Parkinson’s disease.{23036}  

 

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SKU: 12006 - 50 mg Category:

Description

Inhibits PKCδ (IC50 = 3 μM), CAM kinase III, and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 μM, respectively); stimulates autophagy by targeting a signaling cascade upstream of mTORC1

Formal name: (2E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one

Synonyms:  Mallotoxin|NSC 56346|NSC 94525

Molecular weight: 516.5

CAS: 82-08-6

Purity: ≥90%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection

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