A non-selective dopamine receptor agonist (pEC50s = 9.6

Rotigotine – 10 mg

Brand:
Cayman
CAS:
99755-59-6
Storage:
-20
UN-No:
Non-Hazardous - /

Rotigotine is a non-selective dopamine receptor agonist with pEC50 values of 9.6, 10.4, 8.2, 7.7, and 7.7 for D1, D2, D3, D4, and D5, respectively.{32322} It demonstrates a high-affinity for D1, D2, and D3 with lesser affinity for D4 and D5 receptor subtypes.{32322} This binding profile is similar to that of apomorphine (Item No. 16094) and pergolide but differentiated from that of pramipexole (Item No. 11981) and ropinirole, which have a more narrow profile of receptor specificity.{32322} Each of these agonists demonstrates anti-Parkinsonian effects in animal and clinical models through their ability to directly activate dopamine receptors.{32322}  

 

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SKU: 20246 - Category:

Description

A non-selective dopamine receptor agonist (pEC50s = 9.6, 10.4, 8.2, 7.7, and 7.7 for D1, D2, D3, D4, and D5, respectively) with anti-Parkinsonian effects in animal and clinical models

Formal name: (6S)-5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol

Synonyms:  N-0923|SPM 962

Molecular weight: 315.5

CAS: 99755-59-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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