A potent HMG-CoA reductase inhibitor (IC50 = 5 nM); a fully-synthetic inhibitor that is designed to maximize the points of contact with

Rosuvastatin (calcium salt) – 10 mg

Brand:
Cayman
CAS:
147098-20-2
Storage:
-20
UN-No:
Non-Hazardous - /

Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.{15082} Rosuvastatin is a potent HMG-CoA reductase inhibitor (IC50 = 5 nM).{15309,15082} It is a fully-synthetic inhibitor that is designed to maximize the points of contact with, and inhibition of, HMG-CoA reductase.{15309} Formulations containing rosuvastatin reduce low-density lipoprotein (LDL) and C-reactive protein and increase high-density lipoprotein (HDL) in humans.{16178,30471}  

 

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Description

A potent HMG-CoA reductase inhibitor (IC50 = 5 nM); a fully-synthetic inhibitor that is designed to maximize the points of contact with, and inhibition of, HMG-CoA reductase,

Formal name: (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid, hemicalcium salt

Synonyms: 

Molecular weight: 501.6

CAS: 147098-20-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins

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