Description
A reactivator of p53; impairs the interaction between FAK and p53 and restores p53 transcriptional activity at 111, 333, and 1000 µM; reverses FAK-mediated suppression of the expression of p53-dependent p21, MDM2, and Bax in wild-type p53 HCT116 colon and MCF-7 breast cancer cells, but not in p53 mutant SW620 colon cancer cells at 1-50 µM; potentiates the pro-apoptotic effect of doxorubicin and 5-fluorouracil in p53+/+, but not p53-/-, HCT116 cells at 10 µM; reduces tumor growth and activates p21 in p53+/+, but not p53-/- tumors, in HCT116 mouse xenograft models at 60 mg/kg
Formal name: 1-(phenylmethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane, monobromide
Synonyms:
Molecular weight: 311.2
CAS: 29574-21-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53
