An internal standard for the quantification of rosiglitazone by GC- or LC-MS

Rosiglitazone-d3 – 1 mg

Brand:
Cayman
CAS:
1132641-22-5
Storage:
-20
UN-No:
Non-Hazardous - /

Rosiglitazone-d3 is intended for use as an internal standard for the quantification of rosiglitazone (Item Nos. 71740 | 11884 | 71742) by GC- or LC-MS. Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor γ (PPARγ) that binds to the ligand binding domain (LBD) of PPARγ with a Kd value of 43 nM.{8461} It selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay when used at a concentration of 10 mM. Rosiglitazone also activates full-length PPARγ1 and PPARγ2 in a reporter assay (EC50s = 30 and 100 nM, respectively). It induces differentiation of C3H10T1/2 stem cells to adipocytes when used at a concentration of 1 μM. Rosiglitazone (4 mg/kg) decreases hemoglobin A1c (HbA1c) and fasting blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin (STZ; Item No. 13104) and a high-carbohydrate/high-fat diet.{16286} It also inhibits increases in contusion volume, macrophage infiltration and activation of microglia, and expression of IL-6, MCP1, ICAM1, caspase-3, and Bax in mouse cerebral cortex in a model of traumatic brain injury induced by controlled cortical impact when administered at a dose of 6 mg/kg.{37783} Formulations containing rosiglitazone have been used to improve glycemic control in the treatment of type 2 diabetes.  

 

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Description

An internal standard for the quantification of rosiglitazone by GC- or LC-MS

Formal name: 5-[[4-[2-(methyl-d3-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Synonyms: 

Molecular weight: 360.4

CAS: 1132641-22-5

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neuroprotection

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