Description
A xanthene dye, fluorescein derivative, and photosensitizer; abs/em maxima = 548/567 nm, respectively; binds to S. aureus cells and decreases survival of photoirradiated S. aureus to 0.012% at 1 μM; generates singlet oxygen when exposed to photoirradiation in cell-free assays; induces potassium ion leakage from S. aureus and bovine erythrocytes in the presence of photoirradiation; inhibits CYP3A4/5 and UGT1A6 in human liver microsomes in a light-dependent manner (IC50s = 0.072 and 0.035 μM, respectively, in yellow light, 3.1 and 4.2 μM, respectively, in ambient light, and 3 and 4.2 μM, respectively, in the dark); has been used for staining of live cells, but exhibits both intrinsic and phototoxicity
Formal name: 4,5,6,7-tetrachloro-3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodo-spiro[isobenzofuran-1(3H),9′-[9H]xanthen]-3-one, disodium salt
Synonyms: Acid Red 94|Japan Red 105-1|Red No. 105-1
Molecular weight: 1,017.60
CAS: 632-69-9
Purity: ≥90%
Formulation: A crystalline solid
