An immunomodulator with diverse biological activities; increases the number of myocardial MHC class II-expressing cells

Roquinimex – 5 mg

Brand:
Cayman
CAS:
84088-42-6
Storage:
-20
UN-No:
- 2811 / 6.1

Roquinimex is an immunomodulator with diverse biological activities.{46847,46848,46849,46850} In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis.{46847} It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD).{46848} Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{46849} It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.{46850}  

 

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Description

An immunomodulator with diverse biological activities; increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis at 80 mg/kg; induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic GVHD; decreases colonic MPO activity and mucosal damage in a mouse model of DSS-induced colitis at 300 mg/kg; decreases tumor weight and tumor blood flow in a VHL type 2a paraganglioma mouse xenograft model

Formal name: 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide

Synonyms:  ABR 212616|FCF 89|Linomide|LS 2616|PNU 212616

Molecular weight: 308.3

CAS: 84088-42-6

Purity: ≥98%

Formulation: A solid

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