A mycotoxin first isolated from P. roqueforti that displays neurotoxic properties; activates a P-glycoprotein transport system involved in the efflux of xenobiotics and inhibits cytochrome P450 3A detoxification enzymes

Roquefortine C – 500 µg

Brand:
Cayman
CAS:
58735-64-1
Storage:
-20
UN-No:
Non-Hazardous - /

Roquefortine C is a mycotoxin that was first isolated from a strain of P. roqueforti, a species of Penicillium commercially used to ripen blue-veined cheeses.{24904} It has also been isolated from other members of the Penicillium genus found in contaminated food products where it displays neurotoxic properties.{24905} It has been shown to both activate a P-glycoprotein transport system involved in the efflux of xenobiotics and to inhibit cytochrome P450 3A detoxification enzymes.{24907} It has also been used as a biomarker for penitrem A (Item No. 11347) intoxication.{24906}  

 

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Description

A mycotoxin first isolated from P. roqueforti that displays neurotoxic properties; activates a P-glycoprotein transport system involved in the efflux of xenobiotics and inhibits cytochrome P450 3A detoxification enzymes

Formal name: (3E,5aS,10bR)-10b-(1,1-dimethyl-2-propen-1-yl)-6,10b,11,11aS-tetrahydro-3-(1H-imidazol-5-ylmethylene)-2H-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione

Synonyms:  NSC 292134

Molecular weight: 389.5

CAS: 58735-64-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Toxins|Mycotoxins||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing

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