A dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay); selective for D2 over D1 dopamine receptors (Ki = >100

Ropinirole (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
91374-20-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Ropinirole is a potent dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay).{38497} It is selective for D2 over D1 dopamine receptors (Ki = >100,000 nM) as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM). Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson’s disease induced by MPTP. Formulations containing ropinirole have been used for the treatment of Parkinson’s disease motor dysfunction.  

 

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SKU: 23871 - 25 mg Category:

Description

A dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay); selective for D2 over D1 dopamine receptors (Ki = >100,000 nM), as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM); reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg; induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice; reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of MPTP-induced Parkinson’s disease

Formal name: 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one, monohydrochloride

Synonyms:  SKF 101468A

Molecular weight: 296.8

CAS: 91374-20-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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