A tetracycline antibiotic; has bacteriostatic activity at low concentrations (7.8 μg/ml) and bactericidal activity at high concentrations (15.6 μg/ml) against E. coli; has additive and synergistic effects with penicillin and cephalothin

Rolitetracycline – 25 mg

Brand:
Cayman
CAS:
751-97-3
Storage:
-20
UN-No:
Non-Hazardous - /

Rolitetracycline is a tetracycline antibiotic with bacteriostatic activity at low concentrations (7.8 μg/ml) and bactericidal activity at high concentrations (15.6 μg/ml) against E. coli.{40388} It has additive and synergistic effects with penicillin and cephalothin, respectively, in vitro against 34 E. coli and S. aureus strains. Rolitetracycline is also active against P. falciparum strains (IC50s = 45-208 μM) that are susceptible and resistant to chloroquine (Item No. 14194).{40389} It also reduces amyloid-β (1-40) (Aβ40) fibrilization (IC50 = 59 μM in an immune assay) and completely inhibits Aβ40-induced cellular toxicity at a concentration of 20 μM.{40390}  

 

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SKU: 23479 - 25 mg Category:

Description

A tetracycline antibiotic; has bacteriostatic activity at low concentrations (7.8 μg/ml) and bactericidal activity at high concentrations (15.6 μg/ml) against E. coli; has additive and synergistic effects with penicillin and cephalothin, respectively, in vitro against 34 E. coli and S. aureus strains; active against chloroquine-susceptible and -resistant P. falciparum strains (IC50s = 45-208 μM); reduces Aβ40 fibrilization (IC50 = 59 μM in an immune assay); completely inhibits Aβ40-induced cellular toxicity at a concentration of 20 μM

Formal name: 4-(dimethylamino)-1,4S,4aS,5,5aS,6S,11,12aS-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide

Synonyms:  Pyrrolidinylmethyltetracycline|SQ 15,659

Molecular weight: 527.6

CAS: 751-97-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Tetracyclines||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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