Anti-inflammatory

Rocaglamide – 500 µg

Brand:
Cayman
CAS:
84573-16-0
Storage:
-20
UN-No:
Non-Hazardous - /

Rocaglamide is an anti-inflammatory, insecticidal, and anticancer tetrahydrobenzofuran isolated from Aglaia species. It has been shown to inhibit both TNF-α and the activation of NF-κB in Jurkat T cells with IC50 values in the nanomolar range.{23675} At 25 nM, rocaglamide induces apoptosis in various human leukemia cell lines, activating p38 MAPK/JNK and suppressing ERK.{23676} Rocaglamide also reduces IFN-γ, TNF-α, IL-2, and IL-4 production in peripheral blood T cells at a concentration of 50 nM.{23677} Furthermore, rocaglamide can inhibit the T cell expression of the immune response transcription factor, nuclear factor of activated T cells.{23677}  

 

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Description

Anti-inflammatory, insecticidal, and anticancer tetrahydrobenzofuran isolated from Aglaia species that inhibits TNF-α, NF-κB, NF-AT and various cytokines (IFN-γ, TNF-α, IL-2, and IL-4) with IC50 values in the nanomolar range; induces apoptosis in human leukemia cell lines, activating p38 MAPK/JNK and suppressing ERK

Formal name: (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide

Synonyms:  NSC 326408|Roc-A|Rocaglamide A

Molecular weight: 505.6

CAS: 84573-16-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Cell Signaling|p38 MAPK Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Adaptive Immunity

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