An inhibitor of the protein-protein interaction between MDM2 and p53 (IC50 = 5 nM in a p53-MDM2 HTRF binding assay); inhibits the proliferation of SJSA-1

RO8994 – 5 mg

Brand:
Cayman
CAS:
1309684-94-3
Storage:
-20
UN-No:
Non-Hazardous - /

RO8994 is an inhibitor of the protein-protein interaction between MDM2 and the tumor suppressor p53 in a homogeneous time-resolved fluorescence (HTRF) binding assay (IC50 = 5 nM).{47193} It inhibits the proliferation of SJSA-1, RKO, and HCT116 cells with an average IC50 value of 20 nM and increases apoptosis in SJSA-1 cells in a concentration-dependent manner. RO8994 reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model when administered at doses of 1.56 and 6.25 mg/kg, respectively.  

 

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SKU: 25674 - 5 mg Category:

Description

An inhibitor of the protein-protein interaction between MDM2 and p53 (IC50 = 5 nM in a p53-MDM2 HTRF binding assay); inhibits the proliferation of SJSA-1, RKO, and HCT116 cells (average IC50 = 20 nM); increases apoptosis in SJSA-1 cells in a concentration-dependent manner; reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model at 1.56 and 6.25 mg/kg, respectively.

Formal name: (2’S,3R,4’S,5’R)-N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide

Synonyms: 

Molecular weight: 613.5

CAS: 1309684-94-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis

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