Description
An inhibitor of the protein-protein interaction between MDM2 and p53 (IC50 = 5 nM in a p53-MDM2 HTRF binding assay); inhibits the proliferation of SJSA-1, RKO, and HCT116 cells (average IC50 = 20 nM); increases apoptosis in SJSA-1 cells in a concentration-dependent manner; reduces tumor growth and induces tumor regression in an SJSA-1 osteosarcoma mouse xenograft model at 1.56 and 6.25 mg/kg, respectively.
Formal name: (2’S,3R,4’S,5’R)-N-[4-(aminocarbonyl)-2-methoxyphenyl]-6-chloro-4′-(3-chloro-2-fluorophenyl)-2′-(2,2-dimethylpropyl)-1,2-dihydro-2-oxo-spiro[3H-indole-3,3′-pyrrolidine]-5′-carboxamide
Synonyms:
Molecular weight: 613.5
CAS: 1309684-94-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis
