An IFNAR2 agonist with antiviral activity (EC50 = 200 nM in an anti-HCV replicon assay); exhibits 1:1 binding to the IFNAR2 extracellular domain; induces expression of IFN-stimulated genes without induction of genes encoding inflammatory cytokines and chemokines in vitro and in vivo; reduces HCV titer in HCV-infected humanized liver mice following oral administration

RO8191 – 1 mg

Brand:
Cayman
CAS:
691868-88-9
Storage:
-20
UN-No:
- 2811 / 6.1

RO8191 is an agonist of interferon (IFN) α receptor type 2 (IFNAR2) with antiviral activity (EC50 = 200 nM in an anti-hepatitis C virus (HCV) replicon assay).{39290} It exhibits 1:1 binding to the IFNAR2 extracellular domain, indicating RO8191 and IFNAR2 interact at the cell surface. RO8191 induces expression of IFN-stimulated genes, without induction of genes encoding inflammatory cytokines and chemokines, in HCV replicon cells, several cancer cell lines, and human primary hepatocytes. RO8191 induces expression of IFN-stimulated genes in vivo without induction of inflammatory cytokine and chemokine expression in mice. It also reduces HCV titer in HCV-infected humanized liver mice following oral administration.  

 

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SKU: 20449 - Category:

Description

An IFNAR2 agonist with antiviral activity (EC50 = 200 nM in an anti-HCV replicon assay); exhibits 1:1 binding to the IFNAR2 extracellular domain; induces expression of IFN-stimulated genes without induction of genes encoding inflammatory cytokines and chemokines in vitro and in vivo; reduces HCV titer in HCV-infected humanized liver mice following oral administration,

Formal name: 8-(1,3,4-oxadiazol-2-yl)-2,4-bis(trifluoromethyl)-imidazo[1,2-a][1,8]naphthyridine

Synonyms:  Ro 494-8191

Molecular weight: 373.2

CAS: 691868-88-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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