Ro 67-7476 – 1 mg

Brand:
Cayman
CAS:
298690-60-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM).{22051} It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM).{22053}  

 

Available on backorder

SKU: 11993 - 1 mg Category:

Description

A positive allosteric modulator of mGluR1; enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM); selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at 10 μM; increases the amplitude of mGluR1 EPSCs evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices; activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM),


Formal name: 2S-(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine

Synonyms: 

Molecular weight: 319.4

CAS: 298690-60-5

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience