A selective

Ro 67-4853 – 5 mg

Brand:
Cayman
CAS:
302841-89-0
Storage:
22
UN-No:
Non-Hazardous - /

Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1), enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC50 = 7.16).{22051,22050} While only mildly potentiating mGluR5 signaling, this compound is without effect at mGluR2, mGluR4, or mGluR8, as well as at several other neural receptors.{22051} Ro 67-4853 can also directly activate mGluR1 signaling in baby hamster kidney cells, leading to phosphorylation of ERK1/2 (EC50 = 6.2 nM) and activation of adenylate cyclase (EC50 = 11.7 μM).{22053} Ro 67-4853 can also be used to enhance neuronal stimulation in response to the mGluR1/mGluR5 agonist DHPG, both in vivo and in vitro (EC50 = 95 nM).{22051,22052}  

 

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SKU: 11992 - 5 mg Category:

Description

A selective, positive allosteric modulator of mGluR1, enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC50 = 7.16); directly activates mGluR1 signaling in baby hamster kidney cells, leading to phosphorylation of ERK1/2 (EC50 = 6.2 nM)

Formal name: N-(9H-xanthen-9-ylcarbonyl)-carbamic acid, butyl ester

Synonyms: 

Molecular weight: 325.4

CAS: 302841-89-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience

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