A potent inhibitor of kynurenine 3-hydroxylase (IC50 = 37 nM)

Ro 61-8048 – 10 mg

Brand:
Cayman
CAS:
199666-03-0
Storage:
-20
UN-No:
Non-Hazardous - /

The kynurenine pathway mediates the metabolism of L-tryptophan to NAD+ and is particularly important in neurophysiology. Ro 61-8048 is a potent inhibitor of kynurenine 3-hydroxylase (IC50 = 37 nM), preventing the conversion of kynurenine (Item No. 11305) to 3-hydroxy kynurenine.{24463} Ro 61-8048 inhibition of kynurenine 3-hydroxylase reduces ischemia-mediated neuronal damage in tissues.{24463,24465} Ro 61-8048 can be used in vivo by direct injection.{24464}  

 

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Description

A potent inhibitor of kynurenine 3-hydroxylase (IC50 = 37 nM), preventing the conversion of kynurenine to 3-hydroxy kynurenine; reduces ischemia-mediated neuronal damage in tissues; can be used in vivo by direct injection

Formal name: 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide

Synonyms: 

Molecular weight: 421.4

CAS: 199666-03-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Neuroprotection|Ischemia

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