A COMT inhibitor; prevents L-DOPA-induced dopaminergic neuron loss in primary rat rostral mesencephalic tegmentum cultures (EC50 = 0.1 µM); potentiates L-DOPA and carbidopa-induced reversal of reserpine-induced akinesias in rats and reserpine-induced catalepsy and hypothermia in mice at 30 mg/kg; reduces fibroid volume in the Eker rat model of uterine fibroids at 150 mg/kg

Ro 41-0960 – 5 mg

Brand:
Cayman
CAS:
125628-97-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ro 41-0960 is a catechol-O-methyltransferase (COMT) inhibitor.{48777} It prevents dopaminergic neuron loss induced by L-DOPA (Item No. 13248) in primary rat rostral mesencephalic tegmentum cultures (EC50 = 0.1 µM). Ro 41-0960 (30 mg/kg) potentiates L-DOPA and carbidopa-induced reversal of reserpine-induced akinesias in rats and reserpine-induced catalepsy and hypothermia in mice.{48778} It reduces striatal 3-methyl-DOPA levels and increases striatal dopamine (Item No. 21992) and 3,4-dihydroxyphenylacetic acid (DOPAC; Item No. 24912) levels in rats. Ro 41-0960 (150 mg/kg) also reduces fibroid volume in the Eker rat model of uterine fibroids.{48779}  

 

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SKU: 29621 - 5 mg Category:

Description

A COMT inhibitor; prevents L-DOPA-induced dopaminergic neuron loss in primary rat rostral mesencephalic tegmentum cultures (EC50 = 0.1 µM); potentiates L-DOPA and carbidopa-induced reversal of reserpine-induced akinesias in rats and reserpine-induced catalepsy and hypothermia in mice at 30 mg/kg; reduces fibroid volume in the Eker rat model of uterine fibroids at 150 mg/kg

Formal name: (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-methanone

Synonyms: 

Molecular weight: 277.2

CAS: 125628-97-9

Purity: ≥98%

Formulation: A crystalline solid

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