A cell-permeable

Ro 3306 – 5 mg

Brand:
Cayman
CAS:
872573-93-8
Storage:
-20
UN-No:
Non-Hazardous - /

Cyclin-dependent kinase 1 (Cdk1) complexes with different cyclins, with the cyclin determining substrate specificity. Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM), two CDK complexes which regulate cell cycling.{24139} It also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and serum- and glucocorticoid-induce kinase (Ki = 497 nM) but not Cdk4.{24139} Through its effects on Cdk1, Ro 3306 reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization without the use of microtubule poisons.{24140} Prolonged treatment of cells with Ro 3306 induces apoptosis and this can be augmented in acute myeloid leukemia cells by stimulating p53 activity with nutlin-3.{24141}  

 

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Description

A cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM); also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and SGK (Ki = 497 nM) but not Cdk4; reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization

Formal name: 5Z-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

Synonyms: 

Molecular weight: 351.4

CAS: 872573-93-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Death|Apoptosis

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