A cell-permeable

Ro 20-1724 – 100 mg

Brand:
Cayman
CAS:
29925-17-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 µM).{29744,29745} It weakly inhibits PDE3 with a Ki value greater than 25 µM.{29744} Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species.{29746} It is often used to study cAMP-related functions in vascular cells.{27634}  

 

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Description

A cell-permeable, selective PDE4 inhibitor (IC50 = 2 µM); inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species

Formal name: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone

Synonyms:  4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Molecular weight: 278.4

CAS: 29925-17-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Vasculature||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Immunology & Inflammation

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