A p75NTR ligand; completely inhibits NGF binding to p75NTR in PC12 cells at 100 μM; binds to NGF dimers (Kd = ~1 μM) to induce a conformational change that prevents NGF binding to p75NTR or TrkA; inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells; reverses NGF-induced decreases in β-catenin mRNA expression in

Ro 08-2750 – 5 mg

Brand:
Cayman
CAS:
37854-59-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ro 08-2750 is a p75 neurotrophin receptor (p75NTR) ligand that completely inhibits nerve growth factor (NGF) binding to p75NTR in PC12 cells when used at a concentration of 100 μM.{47722} It also binds to NGF dimers (Kd = ~1 μM) to induce a conformational change that prevents NGF binding to p75NTR or tropomyosin-related kinase A (TrkA). Ro 08-2750 inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells. It reverses NGF-induced decreases in β-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells.{47723}  

 

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SKU: 28772 - 5 mg Category:

Description

A p75NTR ligand; completely inhibits NGF binding to p75NTR in PC12 cells at 100 μM; binds to NGF dimers (Kd = ~1 μM) to induce a conformational change that prevents NGF binding to p75NTR or TrkA; inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells; reverses NGF-induced decreases in β-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells

Formal name: 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-benzo[g]pteridine-8-carboxaldehyde

Synonyms: 

Molecular weight: 270.2

CAS: 37854-59-4

Purity: ≥95%

Formulation: A solid

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