A TRPV4 antagonist (IC50s = 0.42 and 0.66 μM

RN-9893 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
2109450-40-8
Storage:
-20
UN-No:
Non-Hazardous - /

RN-9893 is an antagonist of transient receptor potential vanilloid 4 (TRPV4; IC50s = 0.42 and 0.66 μM, respectively, for the human and rat receptors).{52086} It is selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 μM, respectively). RN-9893 reduces rat TRPV4 activity induced by 4α-phorbol 12,13-didecanoate (4α-PDD; Item No. 20446) or hypotonicity (IC50s = 0.57 and 2.1 μM, respectively, in cell free assays).  

 

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SKU: 29172 - 5 mg Category:

Description

A TRPV4 antagonist (IC50s = 0.42 and 0.66 μM, respectively, for human and rat receptors); selective for TRPV4 over TRPV1, TRPV3, and TRPM8 (IC50s = 10, >30, and 30 μM, respectively); reduces 4α-PDD or hypotonicity-induced rat TRPV4 activity (IC50s = 0.57 and 2.1 μM, respectively, in cell free assays)

Formal name: N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)-benzamide, monohydrochloride

Synonyms: 

Molecular weight: 537

CAS: 2109450-40-8

Purity: ≥98%

Formulation: A solid

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