An HIV-1 Vif inhibitor; inhibits Vif-mediated degradation of the DNA editing enzyme APOBEC3G (IC50s = 10-30 µM); inhibits HIV-1 viral replication (IC50s = 4.5 and 10 µM for nonpermissive CEM and H9 cells

RN-18 – 25 mg

Brand:
Cayman
CAS:
431980-38-0
Storage:
-20
UN-No:
Non-Hazardous - /

RN-18 is an inhibitor of HIV-1 viral infectivity factor (Vif), an HIV-1 regulatory protein that does not have cellular homologs.{40237} RN-18 inhibits Vif-mediated degradation of the DNA editing enzyme APOBEC3G with IC50 values of 10-30 µM in a high-throughput fluorescence screen. It inhibits viral replication of HIV-1 with IC50 values of 4.5 and 10 µM for nonpermissive CEM and H9 cells, respectively, and >100 µM for permissive cells.  

 

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SKU: 23331 - 25 mg Category:

Description

An HIV-1 Vif inhibitor; inhibits Vif-mediated degradation of the DNA editing enzyme APOBEC3G (IC50s = 10-30 µM); inhibits HIV-1 viral replication (IC50s = 4.5 and 10 µM for nonpermissive CEM and H9 cells, respectively, and >100 µM for permissive cells)

Formal name: N-(2-methoxyphenyl)-2-[(4-nitrophenyl)thio]-benzamide

Synonyms: 

Molecular weight: 380.4

CAS: 431980-38-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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