A 5-HT1B and 5-HT1D receptor agonist (Kis = 10.1 and 4.3 nM

Rizatriptan (benzoate salt) – 10 mg

Brand:
Cayman
CAS:
145202-66-0
Storage:
-20
UN-No:
Non-Hazardous - /

Rizatriptan is an orally bioavailable agonist at the serotonin (5-HT) receptor subtypes, 5-HT1B and 5-HT1D, with Ki values of 10.1 and 4.3 nM, respectively.{34530} It is less selective for the 5-HT1A receptor subtype (Ki = 140 nM). Rizatriptan has vasoconstrictive properties, which are more potent in isolated cranial arteries than coronary arteries.{34529} Formulations containing rizatriptan are used to treat patients with migraine headaches.  

 

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Description

A 5-HT1B and 5-HT1D receptor agonist (Kis = 10.1 and 4.3 nM, respectively); orally bioavailable; has vasoconstrictive properties; formulations containing it are used for migraine treatment

Formal name: N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine, monobenzoate

Synonyms:  MK-462

Molecular weight: 391.5

CAS: 145202-66-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Neuroscience

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