A potent and selective agonist for the EP4 receptor (Ki = 0.7

Rivenprost – 1 mg

Brand:
Cayman
CAS:
256382-08-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively).{10581} It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.{10581,18823,18825,18824,18827} Rivenprost has also been used to support wound healing.{18826}  

 

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Description

A potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively); promotes EP4-mediated bone formation, prevention of bone loss related to osteoporosis, osteoblast differentiation, and the stabilization of bone implants; supports wound healing

Formal name: 4-[[2R-[3R-hydroxy-2-[3S-hydroxy-4-[3-(methoxymethyl)phenyl]-1R-buten-1E-yl]-5-oxocyclopentyl]ethyl]thio]-butanoic acid, methyl ester

Synonyms:  ONO-4819

Molecular weight: 450.6

CAS: 256382-08-8

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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