An internal standard for the quantification of ritonavir by GC- or LC-MS

Ritonavir-d6 – 500 µg

Brand:
Cayman
CAS:
1217720-20-1
Storage:
-20
UN-No:
Non-Hazardous - /

Ritonavir-d6 is intended for use as an internal standard for the quantification of ritonavir (Item No. 13872) by GC- or LC-MS. Ritonavir is an HIV protease inhibitor.{24746} It inhibits recombinant HIV-1 protease by 79% when used at a concentration of 0.5 nM. It inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells (EC50 = 25 nM) as well as cell death induced by HIV-1LAI, HIV-2ROD, and HIV-2EHO in human MT-2 cells (IC50s = 0.045, 0.13, and 0.24 μM, respectively).{24746,26076} Ritonavir also inhibits the cytochrome P450 (CYP) isoform CYP3A (IC50 = 0.14 μM).{24198} It inhibits CYP-mediated oxidative metabolism of the HIV protease inhibitors saquinavir (Item No. 9001893), indinavir (Item No. 15150), nelfinavir (Item No. 15144), and amprenavir (Item No. 15369) in rat and human liver microsomes in a concentration-dependent manner.{42447} Ritonavir (10 mg/kg) also prevents decreases in plasma levels of these four compounds in rats. Formulations containing ritonavir have been used in the treatment of HIV-1 infection.  

 

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SKU: 25462 - 500 µg Category:

Description

An internal standard for the quantification of ritonavir by GC- or LC-MS

Formal name: thiazol-5-ylmethyl ((2S,3S,5S)-3-hydroxy-5-((S)-3-methyl-2-(3-methyl-3-((2-(propan-2-yl-1,1,1,3,3,3-d6)thiazol-4-yl)methyl)ureido)butanamido)-1,6-diphenylhexan-2-yl)carbamate

Synonyms: 

Molecular weight: 727

CAS: 1217720-20-1

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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