An HIV protease inhibitor; inhibits recombinant HIV-1 protease by 79% at 0.5 nM; inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells (EC50 = 25 nM); inhibits cell death induced by HIV-1LAI

Ritonavir – 100 mg

Brand:
Cayman
CAS:
155213-67-5
Storage:
-20
UN-No:
Non-Hazardous - /

Ritonavir is an HIV protease inhibitor.{24746} It inhibits recombinant HIV-1 protease by 79% when used at a concentration of 0.5 nM. It inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells (EC50 = 25 nM) as well as cell death induced by HIV-1LAI, HIV-2ROD, and HIV-2EHO in human MT-2 cells (IC50s = 0.045, 0.13, and 0.24 μM, respectively).{24746,26076} Ritonavir also inhibits the cytochrome P450 (CYP) isoform CYP3A (IC50 = 0.14 μM).{24198} It inhibits CYP-mediated oxidative metabolism of the HIV protease inhibitors saquinavir (Item No. 9001893), indinavir (Item No. 15150), nelfinavir (Item No. 15144), and amprenavir (Item No. 15369) in rat and human liver microsomes in a concentration-dependent manner.{42447} Ritonavir (10 mg/kg) also prevents decreases in plasma levels of these four compounds in rats. Formulations containing ritonavir have been used in the treatment of HIV-1 infection.  

 

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Description

An HIV protease inhibitor; inhibits recombinant HIV-1 protease by 79% at 0.5 nM; inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells (EC50 = 25 nM); inhibits cell death induced by HIV-1LAI, HIV-2ROD, and HIV-2EHO in human MT-2 cells (IC50s = 0.045, 0.13, and 0.24 μM, respectively); inhibits the CYP isoform CYP3A (IC50 = 0.14 μM); inhibits CYP-mediated oxidative metabolism of saquinavir, indinavir, nelfinavir, and amprenavir in rat and human liver microsomes; prevents decreases in plasma levels of these four compounds in rats at 10 mg/kg

Formal name: (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl ester

Synonyms:  A-84538|ABT-538|NSC 693184|RTV

Molecular weight: 720.9

CAS: 155213-67-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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