An aminobisphosphonate and antimalarial agent that inhibits bone resorption; inhibits growth of P. falciparum in vitro (IC50 = 20.3 µM) and P. berghei in vivo (25 mg/kg for one week); inhibits protein prenylation by preventing transfer of a farnesyl pyrophosphate group to parasite proteins

Risedronate (sodium salt) – 250 mg

Brand:
Cayman
CAS:
115436-72-1
Storage:
-20
UN-No:
Non-Hazardous - /

Risedronate is a heterocyclic orally active aminobisphosphonate.{32680} Like other bisphosphonates, it inhibits bone resorption.{32679,32680} In addition, it has antimalarial activity and inhibits growth of P. falciparum in vitro (IC50 = 20.3 µM) and P. berghei in vivo (25 mg/kg for one week).{35110} It also inhibits protein prenylation by preventing the transfer of a farnesyl pyrophosphate group to parasite proteins. Formulations containing risedronate have been used to reduce fracture risk in both age- and steroid-related osteoporosis.{21586,32679,32680}  

 

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Description

An aminobisphosphonate and antimalarial agent that inhibits bone resorption; inhibits growth of P. falciparum in vitro (IC50 = 20.3 µM) and P. berghei in vivo (25 mg/kg for one week); inhibits protein prenylation by preventing transfer of a farnesyl pyrophosphate group to parasite proteins

Formal name: P,P’-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-phosphonic acid, monosodium salt

Synonyms: 

Molecular weight: 305.1

CAS: 115436-72-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling

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