Description
A prodrug form of the pro-apoptotic compound cRIPGBM; converted to cRIPGBM in GBM-1 GBM CSCs but not primary HLFs; induces apoptosis in GBM CSCs (EC50 = ≤500 nM); selectively reduces survival of GBM-1 cells (EC50 = 0.22 μM) over human neural stem cells, primary human astrocytes, and primary HLF cells (EC50s = 1.7, 2.9, and 3.5 μM, respectively); reduces tumor growth in a GBM mouse xenograft model using patient-derived GBM-39 cells engineered to express IRFP720 at 50 mg/kg twice per day
Formal name: N-[1,4-dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]-acetamide
Synonyms:
Molecular weight: 428.5
CAS: 355406-76-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Cancer|Cell Death
